Engine noise is quite loud at take-off, and can be bothersome at cruise, but a good set of headphones will dampen the noise enough to sleep.
I had to wake her up to go to the lav, which is close but far enough away so noise and odors don't offend. My wife was able to get a solid 6 hours on one stretch. Another benefit is no bumping of the elbow or knee every time someone walks by allowing for uninterrupted sleep. The extra room next the window is good for my big frame and the extra room next to the aisle is nice to have room to stretch without blocking the aisle. This is the best economy seat for travelling couples as there is no DMS.
We requested 70A and 70C in both directions. This 777-300ER was used on the long-hop ORD to PVO PVO to ORD. We booked on China Eastern to Manila because of a very attractive price.